Neural mechanisms of drug reinforcement. Further, it will be interesting to see if drug-induced firing patterns of dopaminergic neurons that co-release both glutamate and dopamine are different from dopaminergic neurons that release dopamine only. In vivo recordings of single neuronal activity in the NAcc have shown that different sets of accumbal neurons are activated during the different phases pre lever press, during the actual drug infusion, post lever press of cocaine and nicotine self-administration Peoples et al. Electrophysiological studies suggest that repeated exposure to alcohol facilitates presynaptic and postsynaptic glutamate transmission Zhu et al. Intracranial self-stimulation to evaluate abuse potential of drugs.
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